Background:  Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH5 (dynein, axonemal, heavy chain 5), also known as HL1, PCD, CILD3 or KTGNR, is a 4,624 amino acid member of the dynein family and functions to produce force toward the minus ends of microtubules and may play an important role in the structural and functional integrity of cellular cilia. Defects in the gene encoding DNAH5 are the cause of primary ciliary dyskinesia type 3 (CILD3) and Kartagener syndrome type 2 (KTGS2), both of which are characterized by ciliary abnormalities.

Description: Rabbit polyclonal to DNAH5

Immunogen: KLH conjugated synthetic peptide derived from DNAH5

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 529 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.