HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

我公司新研發(fā)的HMG-CoA reductase（3-羥-3-甲基戊二酰輔酶A還原酶）抗體以及配對(duì)磷酸化HMG-CoA reductase (pSer871)抗體已經(jīng)通過(guò)檢驗(yàn)測(cè)試，可以應(yīng)用于蛋白印跡（WB），免疫組化（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附試驗(yàn)（ELISA），免疫沉淀（IP），免疫熒光（IF）實(shí)驗(yàn)。具體信息如下：

編號(hào)           產(chǎn)品名稱(chēng)

PR-1030，     HMG-CoA reductase Antibody

PR-1030P，   HMG-CoA reductase (pSer871) Antibody

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鎮(zhèn)江厚普生物科技有限公司銷(xiāo)售部

2013-07-10