Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor mediated signaling, and transcription. PRMT4, also known as CARM1, catalyses the mono- and asymmetric dimethylation of arginine residues in several proteins involved in DNA packaging, transcription regulation and mRNA stability. PRMT4 methylates R2, R17 and R26 of histone H3 and cooperates synergistically with p300/CBP and p160 coactivators to enhance transcriptional activation by nuclear receptors. PRMT4 also methylates several non-histone proteins, including transcriptional coactivators such as p300/CBP, splicing factors and RNA binding proteins. PRMT4 is also a co-activator of p53, facilitating p53-mediated transcription through the methylation of histones H3 and H4.

我公司新研發(fā)的PRMT4（蛋白精胺酸N-甲基轉(zhuǎn)移酶4）抗體以及配對磷酸化PRMT4(phospho S228)抗體已經(jīng)通過檢驗測試，可以應用于蛋白印跡（WB），免疫組化（IHC），免疫細胞化學（ICC），酶聯(lián)免疫吸附試驗（ELISA），免疫沉淀（IP），免疫熒光（IF）實驗。具體信息如下：

編號           產(chǎn)品名稱

PR-1006，     PRMT4 Antibody

PR-1006P，   PRMT4 (phospho S228) Antibody

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鎮(zhèn)江厚普生物科技有限公司銷售部

2013-07-10