Background:  Tetraspanins are a group of hydrophobic membrane proteins that interact with a wide variety of proteins including intracellular signaling molecules, integrins and membrane receptors. Members of the tetraspanin family are characterized by the presence of four hydrophobic domains and play a role in cell development, activation, growth and motility. TSPAN1 (tetraspanin 1), also known as NET1, TM4C or TM4SF, is a 241 amino acid multi-pass membrane protein that localizes to the lysosome membrane. Overexpressed in many human cancers, TSPAN1 is suggested to play an important role in colon cancer progression and in gastric cancer cell migration and invasion. TSPAN1 may also be an important breast cancer suppressor gene. The gene encoding TSPAN1 is located on human chromosome 1p34.1. Chromosome 1 spans about 260 million base pairs, makes up 8% of the human genome and contains approximately 3,000 genes.

Description: Rabbit polyclonal to TSPAN1

Immunogen: KLH conjugated synthetic peptide derived from TSPAN1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.