Background:  CNKSR3 (connector enhancer of kinase suppressor of ras 3), also known as CNK homolog protein 3, CNKSR family member 3 or maguin-like protein, is a 555 amino acid protein that belongs to the CNKSR family. Suggested to play a role in transepithelial sodium transport, CNKSR3 mediates aldosterone-induced and ENaC-mediated sodium transport, and is upregulated by aldosterone. CNKSR3 contains one SAM (sterile α motif) domain, a CRIC domain, DUF1170 domain and a single PDZ (DHR) domain. The gene encoding CNKSR3 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Description: Rabbit polyclonal to CNKSR3

Immunogen: KLH conjugated synthetic peptide derived from CNKSR3

Specificity:  ·Reacts with Human, Mouse, Pig, Dog and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 62 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.