Background: COMMD family members are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Of the ten family members, the role of COMMD1, also known as MURR1, is best characterized, functioning to inhibit TNF-induced NF˚B p50 and to facilitate biliary copper excretion within hepatocytes. Most, if not all, COMMD proteins have been found to play a role in the regulation of NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis and in the regulation of the ubiquitin pathway. As a member of the COMMD family, COMM domain-containing protein 8 is a 183 amino acid protein that is widely expressed with highest expression in thyroid.

Description: Rabbit polyclonal to COMMD8

Immunogen: KLH conjugated synthetic peptide derived from COMMD8

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 21 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.