Background:  USHSA (Usher syndrome type-3) is thought to be involved in the maintenance of the inner ear and retina, specifically playing a role in excitory ribbon synapse junctions between hair cells and cochlear ganglion cells, as well as in analogous synapses within the retina. Defects in the gene encoding USH3A are the cause of Usher syndrome type 3 (USH3), a genetically heterogeneous condition characterized by postlingual progressive deafness and onset of retinitis pigmentosa in the second decade of life. TMEM12 (Transmembrane protein 12), also known as USH3AL1 or CLRN3, is a 226 amino acid multi-pass membrane protein that belongs to the clarin family. Existing as two alternatively spliced isoforms TMEM12 may display similar functions as USHSA.

Description: Rabbit polyclonal to CLRN3

Immunogen: KLH conjugated synthetic peptide derived from CLRN3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 25 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.