Background:  CD300A, also known as CMRF35H, IRC1, IRC2, IRp60 or IGSF12, is a 299 amino acid single-pass type I membrane protein that localizes to the cell membrane and contains one Ig-like V-type domain. Expressed by mast cells, B-cells, dendritic cells, monocytes, granulocytes and natural killer (NK) cells, CD300A functions as an inhibitory receptor that is thought to help down-regulate the cytolytic activity in NK cells and may also down-regulate the degranulation of mast cells. CD300A exists as multiple alternatively spliced isoforms and is subject to post-translational phosphorylation and glycosylation. The gene encoding CD300A maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

Description: Rabbit polyclonal to IGSF12

Immunogen: KLH conjugated synthetic peptide derived from IGSF12

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 33 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.