Background:  Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH10 (dynein, axonemal, heavy chain 10), also known as KIAA2017 or FLJ38262, is a 4,471 amino acid member of the dynein heavy chain protein family. Expressed primarily in testis and trachea, DNAH10 contains 16 LRR repeats and 5 TPR repeats. DNAH10 is the force generating protein of respiratory cilia.

Description: Rabbit polyclonal to DNAH10

Immunogen: KLH conjugated synthetic peptide derived from DNAH10

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 127 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.