Background: GBP5 (guanylate binding protein 5), also known as GBP-TA antigen, is a 586 amino acid protein that localizes to the cytoplasmic side of the cell membrane. Belonging to the interferon (IFN)-inducible guanylate-binding protein (GBP) family, GBP5 may be involved in the inflammatory response or with cell proliferation and is suggested to have possible cancer-related functions. The gene encoding GBP5 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Description: Rabbit polyclonal to GBP5
Immunogen: KLH conjugated synthetic peptide derived from GBP5
Specificity: ·Reacts with Human, Mouse and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 67 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.