Background: Members of the Bcl-2 family of proteins interact to regulate apoptosis, a process by which multicellular organisms eliminate superflous cells. Various homodimers and heterodimers formed by proteins in this family either promote or inhibit apoptosis. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect on certain hematopoietic cell lines following growth factor withdrawal. Bok, or Bcl-2 related ovarian killer, is highly expressed in ovary, testis, uterus and mammary glands. Bok induces apoptosis in cells, which is suppressible by anti-apoptotic human Bcl-2 family proteins. Bok targets mitochondria and triggers cytochrome c release through a caspase- independent mechanism. Bok contains the conserved Bcl-2 homology (BH) domains 1, 2 and 3, but lacks the BH4 domain. Bok selectively heterodimerizes with some anti-apoptotic members of the Bcl-2 protein family, including Mcl-1 and Bfl-1, but it does not appear to interact with Bcl-2, Bcl-x L and Bcl-w.

Description: Rabbit polyclonal to BOK

Immunogen: KLH conjugated synthetic peptide derived from BOK

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 23 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.