Background: The Dynactin complex is a macromolecular complex that consists of 10-11 distinct subunits. This complex is critical for the function of Dynein, a molecular motor protein. Dynactin plays a role in ER to Golgi transport, spindle formation, chromosome movement, axon guidance, nuclear positioning and the centripetal movement of lysosomes and endosomes. Centractin is a subunit of the Dynactin complex that exists in multiple isoforms. The α isoform, also known as Actin-related protein 1 homolog A (Arp1) and previously referred to as centractin, is the most abundant isoform in the Dynactin complex. The β isoform, also known as Actin-related protein 1 homolog B, shares 90% identity with the α isoform. The two isoforms, α and β, are expressed at a ratio of 15:1 respectively. The backbone filament structure of the Dynactin complex (important for the arrangement of other complex proteins) is composed of 9-11 subunits of α/β-centractin.

Description: Rabbit polyclonal to ACTR1A

Immunogen: KLH conjugated synthetic peptide derived from ACTR1A

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 43 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.