Background: Netrin G1 is a lipid-anchored protein that is structurally related to the netrin family of axon guidance molecules. Netrin G1 does not bind any of the known netrin receptors. Netrin G1 protein has an important role in the developing central nervous system, particularly in axonal guidance, signalling and NMDA receptor function. A translocation that disrupted the netrin G1 gene has been reported in a patient with the early seizure variant of Rett syndrome. Netrin G1 consists of at least 10 isoforms, of which, a number are predominantly anchored to the plasma membrane via glycosyl phosphatidyl-inositol linkages. Netrin G1 transcripts are first detected in midbrain and hindbrain regions by embryonic day 12 and reached highest levels at perinatal stages in various brain regions, including olfactory bulb mitral cells, thalamus, and deep cerebellar nuclei.

Description: Rabbit polyclonal to Netrin G1

Immunogen: KLH conjugated synthetic peptide derived from Netrin G1

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 61 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.