Background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. Protocadherins are spatiotemporally regulated and are localized at synapses in the CNS. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. Unlike the PCDHA and PCDHG genes, PCDB genes do not use constant region exons to produce mRNAs. Expressed by one of the sixteen genes within the beta cluster, PCDHB5 (Protocadherin beta-5) is a 795 amino acid single-pass transmembrane protein that contains six cadherin domains and functions as a potential calcium-dependent cell-adhesion protein, possibly playing a role in the creation and maintenance of neuronal connections.

Description: Rabbit polyclonal to PCDHB5

Immunogen: KLH conjugated synthetic peptide derived from PCDHB5

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 86 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.