Background: The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of neurogenin1, neurogenin2 and neurogenin3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. During mouse neurogenesis, Neurogenin1 and Neurogenin2 are expressed in distinct progenitor populations in the central and peripheral nervous systems. Targeted mutation analyses have shown that Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia and that Neurogenin2 is essential for the determination of precursors for epibranchial placode-derived sensory neurons. The gene which encodes Neurogenin1 maps to human chromosome 5q23-q31.

Description: Rabbit polyclonal to Neurogenin1

Immunogen: KLH conjugated synthetic peptide derived from Neurogenin1

Specificity:  ·Reacts with Human, Mouse, Pig, Dog, Chicken and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 26 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.