Background:  Mesotrypsinogen is an isoform of human Trypsin, belonging to the Trypsin family of serine proteases. Mesotrypsinogen is known to be resistant to common Trypsin inhibitors such as SBTI and SPINK1, which may contribute to pathogenesis of pancreatitis by reducing the protective levels of SPINK1 in the pancreas. A minor pancreatic digestive enzyme that degrades dietary Trypsin inhibitors in the gut, Measotrypsinogen may function to facilitate the digestion of foods rich in natural Trypsin inhibitors. Mesotrypsinogen migrates to the brain and pancreas and operates on peptide linkages involving the carboxyl group of lysine or Arginine. The gene encoding the Mesotrypsinogen protein maps to the locus of T cell receptor b variable orphans on chromosome 9.

Description: Rabbit polyclonal to PRSS3

Immunogen: KLH conjugated synthetic peptide derived from PRSS3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 33 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.