Background: Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA VII, also known as carbonate dehydratase VII, is a highly conserved mammlian carbonic anhydrase. It localizes to the cytoplasm and is ubiquitiously expressed at low levels, but is present at significant levels in brain and salivary glands. CA VII may influence GABAergic excitation in neurons and contribute to the triggering of convulsions common to neurological disorders. Due to the high expression level of CA VII in brain, it may be useful in the development of pharmacologic agents for managing epilepsy and Alzheimer’s disease.

Description: Rabbit polyclonal to CA7

Immunogen: KLH conjugated synthetic peptide derived from CA7

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 30 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/100-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.