Background:  Lrp2 belongs to the LDLR family and contains 17 EGF-like domains, 36 LDL-receptor class A domains and 37 LDL-receptor class B repeats. Lrp2 specifically binds clusterin with high affinity, but also ligands in common with other family members: plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin and calcium. It is invovled in receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. Also it may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.

Description: Rabbit polyclonal to Megalin

Immunogen: KLH conjugated synthetic peptide derived from Megalin

Specificity:  ·Reacts with Human, Mouse, Rabbit, Dog and Rat.

.·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 522 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/100-200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.