Background:   CD98 (4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE) is a disulfide-linked heterodimer composed of a glycosylated heavy chain and a non-glycosylated light chain. CD98 is a scaffolding protein that interacts with basolaterally expressed amino acid transporters and β1 integrins and can alter amino acid transport and cell adhesion, migration and branching morphogenesis. The heavy chain is a type II integral membrane protein. CD98 is expressed on T cells and is upregulated upon T cell activation. CD98 is also present on monocytes and at lower levels on granulocytes, platelets and lymphocytes. Evidence suggests that CD98 may play a role in the regulation of T cell activation and proliferation. Alternate transcriptional splice variants, encoding different isoforms exist for the human CD98 gene.

Description: Rabbit polyclonal to CD98

Immunogen: KLH conjugated synthetic peptide derived from CD98

Specificity:  ·Reacts with Human, Mouse and Rat.

.·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 68 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.