Background:  Collagen Type XI may play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. It is an 1806 amino acid protein belonging to the fibrillar collagen family. Collagen Type XI is thought to play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This protein forms trimers composed of three different chains: α 1(XI), α 2(XI), and α 3(XI). Α 3(XI) is a posttranslational modification of α 1(II). α 1(V) can also be found instead of α 3(XI). Collagen Type XI has three named isoforms (A,B,C) and additional isoforms seem to exist, stemming from alternative usage of exon IIA or exon IIB. Transcripts containing exon IIA or IIB are present in cartilage, but exon IIB is preferentially utilized in transcripts from tendon. Collagen Type XI contains a single collagen binding TSP N-terminal (TSPN) domain. Collagen Type XI is expressed in cartilage, placenta and some tumor or virally transformed cell lines.

Description: Rabbit polyclonal to Collagen XI

Immunogen: KLH conjugated synthetic peptide derived from Collagen XI

Specificity:  ·Reacts with Human, Mouse, Pig, Rabbit and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 181 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/100-500;

·Immunocytochemistry: 1/200;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.