Background:  Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 and MCT2, are characterized by 12 predicted transmembrane domains. SLC16A3 catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta hydroxybutyrate and acetate.

Description: Rabbit polyclonal to SLC16A3

Immunogen: KLH conjugated synthetic peptide derived from SLC16A3

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/200-1000. Predicted Mol wt: 49 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/100-500;

·ELISA: 1/1000;

·Optimal working dilutions must be determined by the end user.