Background:  This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

Description: Rabbit polyclonal to DDB1

Immunogen: KLH conjugated synthetic peptide derived from DDB1

Specificity:  ·Reacts with Human, Mouse, Rabbit, Cow and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 125 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-200;

·Immunocytochemistry: 1/100;

·ELISA: 1/1000;

·Optimal working dilutions must be determined by the end user.