Background:  MLX is a transcription regulator containing 1 basic helix-loop-helix (bHLH) domain. Efficient DNA binding requires dimerization with another bHLH protein. MLX binds DNA as a heterodimer with MAD1, MAD4, MNT and WBSCR14 and can also bind DNA as a homodimer. It forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT and WBSCR14 which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Expression peaks during early stages of organogenesis. MLX exists as 3 named isoforms produced by alternative splicing.

Description: Rabbit polyclonal to MLX

Immunogen: KLH conjugated synthetic peptide derived from MLX

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 33 kDa;

·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

·Immunocytochemistry: 1/100-500;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.