Background:  Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Description: Mouse monoclonal to FAK

Immunogen: Purified recombinant fragment of human FAK expressed in E. Coli.

Specificity:  ·Reacts with Human and Mouse.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 125 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/1000;

·Optimal working dilutions must be determined by the end user.