Background:  CHST7 belongs to the sulfotransferase family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moities during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This protein mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of the family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. CHST7 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7), also known as C6ST-2 (chondroitin 6-sulfotransferase 2), Gn6st-4 (N-acetylglucosamine 6-O-sulfotransferase 4) or GST-5 (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5), is a 486 amino acid protein that belongs to the sulfotransferase 1 family and Gal/GlcNAc/GalNAc subfamily. A single-pass type II membrane protein of the Golgi apparatus membrane, CHST7 is widely expressed and is known to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues.

Description: Rabbit polyclonal to CHST7

Immunogen: KLH conjugated synthetic peptide derived from CHST7

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 54 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.