Background:  Members of the Coronin family are involved in several cellular processes, including cell cycle progression, apoptosis, cytokinesis and gene regulation. Coronin 7, also known as CORO7, crn7 or POD1, is a 925 amino acid protein that predominantly localizes to cytosol. Coronin 7 is occasionally found on vesicle-like cytoplasmic structures of the Golgi apparatus membrane, where it is involved in Golgi complex protein export and morphology. A member of the evolutionarily conserved WD repeat Coronin family, Coronin 7 contains eight WD repeats and exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 16p13.3. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Description: Rabbit polyclonal to CORO7

Immunogen: KLH conjugated synthetic peptide derived from CORO7

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 100 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.