Background:  Members of the T-box (Tbx) gene family share a conserved domain that codes for the T-box, a sequence involved in DNA-binding and protein dimerization. The Tbx gene family is largely conserved throughout metazoan evolution, and is implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system. Embryonic expression of TBX5 has been found in the human retina. TBX5 as well as TBX20 are required for and have non-redundant functions in early heart development. The genes encoding human TBX5 and TBX1 are mutated in cardiac congenital anomaly syndromes. Specifically, mutations in the TBX5 gene have been identified in patients with Holt-Oram syndrome, an autosomal dominant heart-hand syndrome characterized by congenital heart disease and upper limb deformity.

Description: Rabbit polyclonal to TBX5

Immunogen: KLH conjugated synthetic peptide derived from TBX5

Specificity:  ·Reacts with Human, Mouse and Rat.

·Isotype: IgG

Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 58 kDa;

·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

·Immunocytochemistry/Immunofluorescence: 1/100;

·Immunoprecipitation: 1/50;

·ELISA: 1/500;

·Optimal working dilutions must be determined by the end user.