Background: Formation of methylated metabolites is a critical step in the metabolism of inorganic arsenic. Arsenite methyltransferase (cyt19) is localized to the cytoplasm and operates in the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate which is reduced to methylarsonite. Methylarsonite acts as a substrate and is converted into a much less toxic compound dimethylarsinate. cyt19 is highly expressed in liver. Inherited variation in cyt19 may contribute to variation in arsenic metabolism and possibly arsenic-dependent carcinogenesis in humans.
Description: Rabbit polyclonal to CYT19
Immunogen: KLH conjugated synthetic peptide derived from CYT19
Specificity: ·Reacts with Human, Mouse, Pig, Dog and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/100-500. Predicted Mol wt: 42 kDa;
·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;
·Immunocytochemistry/Immunofluorescence: 1/100;
·Immunoprecipitation: 1/50;
·ELISA: 1/500;
·Optimal working dilutions must be determined by the end user.