ABI1（Abelson interactor 1） may act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

我公司新研發(fā)的ABI1(SSH3BP1蛋白)抗體以及配對(duì)磷酸化ABI1 (phospho Y328)抗體已經(jīng)通過檢驗(yàn)測(cè)試，可以應(yīng)用于蛋白印跡（WB），免疫組化（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附試驗(yàn)（ELISA），免疫沉淀（IP），免疫熒光（IF）實(shí)驗(yàn)。具體信息如下：

編號(hào)           產(chǎn)品名稱

PR-1007，     ABI1 Antibody

PR-1007P，   ABI1 (phospho Y328) Antibody

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鎮(zhèn)江厚普生物科技有限公司銷售部

2014-08-22